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<\/p>\n

\nDie Infertilit\u00e4t von Paaren ist ein weltweites Problem, dass in 40-50% der F\u00e4lle auf Fertilit\u00e4tsst\u00f6rungen beim Mann zur\u00fcckzuf\u00fchren ist. Eine grundlegende Ursache f\u00fcr die m\u00e4nnliche Infertilit\u00e4t ist ein Defekt in der Spermienmotilit\u00e4t. Obwohl einige, f\u00fcr die Spermienmotilit\u00e4t wichtige Signalwege bekannt sind, ist die vierdimensionale Spermienschwimmbewegung und deren Bedeutung f\u00fcr die Fertilisation der Oozyte noch nicht vollst\u00e4ndig verstanden.
Der Forschungsschwerpunkt von Frau Dr. Wieseh\u00f6fer liegt daher in der vierdimensionalen Bewegungsanalyse von Spermien mittels der digital-holografischen Mikroskopie (DHM). Mithilfe dieser Technik sind wir erstmals in der Lage neben der Schwimmtrajektorie auch die Bewegung des Spermienschwanzes (Flagellums) in 4D darzustellen. Die Verwendung von spezifischen Messkammern erlaubt uns Bewegungsanalysen unter definierten Versuchsbedingungen durchzuf\u00fchren. Der Einfluss verschiedener Faktoren auf die 4D Spermienbewegung kann mittels einer Perfusionskammer untersucht werden. Des Weiteren erm\u00f6glicht ein in das DHM inkludiertes Fluoreszenzmodul die gleichzeitige Analyse biochemischer Ver\u00e4nderungen, die w\u00e4hrend des Fertilisationsprozesses auftreten. Um neue Erkenntnisse zum biologischen Grundverst\u00e4ndnis der Spermienbewegung, insbesondere der Flagellenbewegung kurz vor der Befruchtung, zu erhalten, untersucht Frau Dr. Wieseh\u00f6fer die Spermienmotilit\u00e4t zu definierten Fertilisationszust\u00e4nden (aktiviert vs. hyperaktiviert) sowie nach Kontakt zur Zona Pellucida, einer Glykoproteinmatrix, die die Eizelle umgibt. Zus\u00e4tzlich wird der Einfluss verschiedener Ionenkan\u00e4le (CatSper, Hv1), sowie \u00c4nderungen des intrazellul\u00e4ren pH-Werts auf die vierdimensionale Spermienbewegung untersucht. In diesem Zusammenhang werden weitere Methoden wie High-speed Imaging und Computer-Assistierte Spermienanalyse (CASA) verwendet.<\/span><\/p>\n

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<\/p>\n

\nInfertility of couples is a worldwide problem, which depends in 40-50% of these cases on the fertility dysfunction of men. Although some causes of male infertility and some important signaling pathways of sperm motility are already known, the four dimensional sperm movement and its meaning for the fertilization process of the oocyte is not yet fully understood.
The research focus of Dr. Wieseh\u00f6fer relies on the four dimensional movement analysis of sperm using digital-holographic Microscopy (DHM). Besides the analysis of sperm trajectories, this technique allows the analysis of the sperm tail (flagellum) movement in 4D for the first time. The use of specific measurement chambers enable us to perform motility analysis under defined trial conditions. The influence of different factors on the 4D sperm movement can be analyzed with the use of perfusion chambers. Furthermore, a fluorescence module included to the DHM allows us a parallel analysis of biochemical changes, which occur during the fertilization process. To gain new insights into the biological understanding of sperm motility especially of flagellar movement, Dr Wieseh\u00f6fer examine the sperm motility to defined fertility conditions (activated vs. hyperactivated) and after contact to the zona pellucida, a glycoprotein matrix, which surrounds the oocyte. Additionally, the influence of different ion channels (CatSper, Hv1) as well as changes of intracellular pH on four dimensional sperm movement will be analyzed. In this context, other methods like high-speed imaging and computer-assisted sperm analysis (CASA) will be used.<\/span><\/p>\n

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