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<\/p>\n

Die Forschungsprojekte von Ruth Gr\u00fcmmer fokussieren sich auf die<\/span><\/strong>\u00a0molekularen Mechanismen der weiblichen Reproduktion und ihrer St\u00f6rungen. Diese umfassen:<\/span><\/p>\n

\u00a0<\/span><\/p>\n

    \n
  • Analyse der zellu<\/span>l\u00e4ren und molekularen Mechanismen der Pathogenese und Entwicklung neuer Therapieans\u00e4tze f\u00fcr die Behandlung der Endometriose<\/span><\/strong><\/li>\n
  • Regulation der feto-maternalen Interaktion bei der Embryoimplantation<\/span>\u00a0<\/span><\/li>\n
  • Signalwege und Epithel-Stroma-Interaktion bei der Induktion und Regulation der Dezidualisierung<\/span><\/li>\n
  • Rolle von Zellkontaktproteinen f\u00fcr die Dezidualisierung, Implantation und Plazentation<\/span><\/li>\n
  • Endometriale 2D- und 3D-Zellkultursysteme \/ Mausmodelle<\/span><\/li>\n<\/ul>\n

    \u00a0<\/span><\/strong><\/p>\n

      \n
    • The projects of Ruth Gr\u00fcmmer focus\u00a0<\/span><\/strong>on the molecular mechanisms in female reproduction and their dysfunction. These include:<\/span><\/li>\n
    • cellu<\/span>lar and molecular mechanisms of the pathogenesis and development of novel therapeutical approaches for the treatment of\u00a0<\/span><\/strong>endometriosis<\/span><\/li>\n
    • regulation of the feto-maternal interaction during embryo implantation<\/span><\/li>\n
    • signalling and epithel-stromal interaction in the induction and regulation of decidualization<\/span><\/li>\n
    • role of cell contact proteins for decidualization, implantation and placental development<\/span><\/li>\n
    • 2D and 3D endometrial cell culture systems \/ mouse models<\/span><\/li>\n<\/ul>\n

      \n<\/div>

      <\/p>\n

      <\/h3>\n

      References<\/h3>\n

      \n<\/div><\/div><\/div><\/div><\/div><\/section>

      \r\n\n
      \n\n
      \n\n Platt F, Moyer J, Singer BB, Baston-B\u00fcst D, Wennemuth G, Bielfeld AP and Gr\u00fcmmer R. <\/span>\n Forskolin versus cAMP-Induced Decidualization and Survival of Endometrial Stromal Cells of Endometriosis Patients. <\/span>\n (2023) Reprod Sci.<\/span> 30, <\/strong>2680-2691<\/span>\n\n <\/div>\n\n<\/div>\n\n\n
      \n\n
      \n\n Grund SC, Wu XX, M\u00fcller D, Wennemuth G and Gr\u00fcmmer R. <\/span>\n Impact of endometrial claudin-3 deletion on murine implantation, decidualization, and embryo development\u2020. <\/span>\n (2022) Biol Reprod.<\/span> 107, <\/strong>984-997<\/span>\n\n <\/div>\n\n<\/div>\n\n\n
      \n\n
      \n\n Petri T, Dankert D, Demond H, Wennemuth G, Horsthemke B and Gr\u00fcmmer R. <\/span>\n In vitro postovulatory oocyte aging affects H3K9 trimethylation in two-cell embryos after IVF. <\/span>\n (2020) Ann Anat.<\/span> 227, <\/strong>151424<\/span>\n\n <\/div>\n\n<\/div>\n\n\n
      \n\n
      \n\n Koch Y, Wimberger P and Gr\u00fcmmer R. <\/span>\n Human chorionic gonadotropin induces decidualization of ectopic human endometrium more effectively than forskolin in an in-vivo endometriosis model. <\/span>\n (2018) Exp Biol Med (Maywood).<\/span> 243, <\/strong>953-962<\/span>\n\n <\/div>\n\n<\/div>\n\n\n
      \n\n
      \n\n Grund S and Gr\u00fcmmer R. <\/span>\n Direct Cell\u207bCell Interactions in the Endometrium and in Endometrial Pathophysiology. <\/span>\n (2018) Int J Mol Sci.<\/span> 19, <\/strong><\/span>\n\n <\/div>\n\n<\/div>\n\n\n
      \n\n
      \n\n Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Fr\u00f6hlich T, Arnold GJ, Gr\u00fcmmer R, Horsthemke B and Eichenlaub-Ritter U. <\/span>\n Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. <\/span>\n (2016) Hum Reprod.<\/span> 31, <\/strong>133-49<\/span>\n\n <\/div>\n\n<\/div>\n\n\n
      \n\n
      \n\n Schumann S, Buck VU, Classen-Linke I, Wennemuth G and Gr\u00fcmmer R. <\/span>\n Claudin-3, claudin-7, and claudin-10 show different distribution patterns during decidualization and trophoblast invasion in mouse and human. <\/span>\n (2015) Histochem Cell Biol.<\/span> 144, <\/strong>571-85<\/span>\n\n <\/div>\n\n<\/div>\n\n\n
      \n\n
      \n\n S\u00f6hngen L, Schmidt M, Wimberger P, Kimmig R and Gr\u00fcmmer R. <\/span>\n Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture. <\/span>\n (2014) J Reprod Immunol.<\/span> 106, <\/strong>50-7<\/span>\n\n <\/div>\n\n<\/div>\n\n\n
      \n\n
      \n\n Dankert D, Demond H, Trapphoff T, Heiligentag M, Rademacher K, Eichenlaub-Ritter U, Horsthemke B and Gr\u00fcmmer R. <\/span>\n Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes. <\/span>\n (2014) PLoS One.<\/span> 9, <\/strong>e108907<\/span>\n\n <\/div>\n\n<\/div>\n\n\n
      \n\n
      \n\n Demond H, Trapphoff T, Dankert D, Heiligentag M, Gr\u00fcmmer R, Horsthemke B and Eichenlaub-Ritter U. <\/span>\n Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. <\/span>\n (2016) PLoS One.<\/span> 11, <\/strong>e0162722<\/span>\n\n <\/div>\n\n<\/div>\n\n<\/div><\/div><\/div><\/div><\/div><\/section>

      <\/p>Search PubMed<\/a><\/div><\/div><\/div><\/div><\/div><\/section>

      <\/div><\/div>
      <\/div><\/div>
      <\/div><\/div>
      <\/div><\/div><\/div><\/div><\/section><\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"ngg_post_thumbnail":0},"team_cats":[200],"_links":{"self":[{"href":"https:\/\/www.anatomie-essen.de\/wp-json\/wp\/v2\/team\/2380"}],"collection":[{"href":"https:\/\/www.anatomie-essen.de\/wp-json\/wp\/v2\/team"}],"about":[{"href":"https:\/\/www.anatomie-essen.de\/wp-json\/wp\/v2\/types\/team"}],"wp:attachment":[{"href":"https:\/\/www.anatomie-essen.de\/wp-json\/wp\/v2\/media?parent=2380"}],"wp:term":[{"taxonomy":"team_cat","embeddable":true,"href":"https:\/\/www.anatomie-essen.de\/wp-json\/wp\/v2\/team_cats?post=2380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}