Room

6. OG R 40

Contact Information

Call: +49 201 723 4290

Email: ruth.gruemmer@uk-essen.de

Ruth Grümmer

Prof. Dr. rer. nat.

Die Forschungsprojekte von Ruth Grümmer fokussieren sich auf die molekularen Mechanismen der weiblichen Reproduktion und ihrer Störungen. Diese umfassen:

 

  • Analyse der zellulären und molekularen Mechanismen der Pathogenese und Entwicklung neuer Therapieansätze für die Behandlung der Endometrios
  • Regulation der feto-maternalen Interaktion bei der Embryoimplantation 
  • Signalwege und Epithel-Stroma-Interaktion bei der Induktion und Regulation der Dezidualisierung
  • Rolle von Zellkontaktproteinen für die Dezidualisierung, Implantation und Plazentatio
  • Endometriale 2D- und 3D-Zellkultursysteme / Mausmodelle

 

  • The projects of Ruth Grümmer focus on the molecular mechanisms in female reproduction and their dysfunction. These include:
  • cellular and molecular mechanisms of the pathogenesis and development of novel therapeutical approaches for the treatment of endometriosis
  • regulation of the feto-maternal interaction during embryo implantation
  • signalling and epithel-stromal interaction in the induction and regulation of decidualization
  • role of cell contact proteins for decidualization, implantation and placental development
  • 2D and 3D endometrial cell culture systems / mouse models

References

Petri T, Dankert D, Demond H, Wennemuth G, Horsthemke B and Grümmer R. In vitro postovulatory oocyte aging affects H3K9 trimethylation in two-cell embryos after IVF. (2020) Ann. Anat.. 227, 151424
Koch Y, Wimberger P and Grümmer R. Human chorionic gonadotropin induces decidualization of ectopic human endometrium more effectively than forskolin in an in-vivo endometriosis model. (2018) Exp. Biol. Med. (Maywood). 243, 953-962
Grund S and Grümmer R. Direct Cell⁻Cell Interactions in the Endometrium and in Endometrial Pathophysiology. (2018) Int J Mol Sci. 19,
Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Fröhlich T, Arnold GJ, Grümmer R, Horsthemke B and Eichenlaub-Ritter U. Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. (2016) Hum. Reprod.. 31, 133-49
Schumann S, Buck VU, Classen-Linke I, Wennemuth G and Grümmer R. Claudin-3, claudin-7, and claudin-10 show different distribution patterns during decidualization and trophoblast invasion in mouse and human. (2015) Histochem. Cell Biol.. 144, 571-85
Söhngen L, Schmidt M, Wimberger P, Kimmig R and Grümmer R. Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture. (2014) J. Reprod. Immunol.. 106, 50-7
Zaun G, Zahedi Y, Maderwald S, Orzada S, Pütter C, Scherag A, Winterhager E, Ladd ME and Grümmer R. Repetitive exposure of mice to strong static magnetic fields in utero does not impair fertility in adulthood but may affect placental weight of offspring. (2014) J Magn Reson Imaging. 39, 683-90
Zahedi Y, Zaun G, Maderwald S, Orzada S, Pütter C, Scherag A, Winterhager E, Ladd ME and Grümmer R. Impact of repetitive exposure to strong static magnetic fields on pregnancy and embryonic development of mice. (2014) J Magn Reson Imaging. 39, 691-9
Dankert D, Demond H, Trapphoff T, Heiligentag M, Rademacher K, Eichenlaub-Ritter U, Horsthemke B and Grümmer R. Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes. (2014) PLoS ONE. 9, e108907
Demond H, Trapphoff T, Dankert D, Heiligentag M, Grümmer R, Horsthemke B and Eichenlaub-Ritter U. Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. (2016) PLoS ONE. 11, e0162722