Ruth Grümmer

Prof. Dr. rer. nat.

Die Forschungsprojekte von Ruth Grümmer fokussieren sich auf die molekularen Mechanismen der weiblichen Reproduktion und ihrer Störungen. Diese umfassen:

Analyse der zellulären und molekularen Mechanismen der Pathogenese und Entwicklung neuer Therapieansätze für die Behandlung der Endometriose
Regulation der feto-maternalen Interaktion bei der Embryoimplantation
Signalwege und Epithel-Stroma-Interaktion bei der Induktion und Regulation der Dezidualisierung
Rolle von Zellkontaktproteinen für die Dezidualisierung, Implantation und Plazentation
Endometriale 2D- und 3D-Zellkultursysteme / Mausmodelle

The projects of Ruth Grümmer focus on the molecular mechanisms in female reproduction and their dysfunction. These include:
cellular and molecular mechanisms of the pathogenesis and development of novel therapeutical approaches for the treatment of endometriosis
regulation of the feto-maternal interaction during embryo implantation
signalling and epithel-stromal interaction in the induction and regulation of decidualization
role of cell contact proteins for decidualization, implantation and placental development
2D and 3D endometrial cell culture systems / mouse models

References

Platt F, Moyer J, Singer BB, Baston-Büst D, Wennemuth G, Bielfeld AP and Grümmer R. Forskolin versus cAMP-Induced Decidualization and Survival of Endometrial Stromal Cells of Endometriosis Patients. (2023) Reprod Sci. 30, 2680-2691

Grund SC, Wu XX, Müller D, Wennemuth G and Grümmer R. Impact of endometrial claudin-3 deletion on murine implantation, decidualization, and embryo development†. (2022) Biol Reprod. 107, 984-997

Petri T, Dankert D, Demond H, Wennemuth G, Horsthemke B and Grümmer R. In vitro postovulatory oocyte aging affects H3K9 trimethylation in two-cell embryos after IVF. (2020) Ann Anat. 227, 151424

Koch Y, Wimberger P and Grümmer R. Human chorionic gonadotropin induces decidualization of ectopic human endometrium more effectively than forskolin in an in-vivo endometriosis model. (2018) Exp Biol Med (Maywood). 243, 953-962

Grund S and Grümmer R. Direct Cell⁻Cell Interactions in the Endometrium and in Endometrial Pathophysiology. (2018) Int J Mol Sci. 19,

Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Fröhlich T, Arnold GJ, Grümmer R, Horsthemke B and Eichenlaub-Ritter U. Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. (2016) Hum Reprod. 31, 133-49

Schumann S, Buck VU, Classen-Linke I, Wennemuth G and Grümmer R. Claudin-3, claudin-7, and claudin-10 show different distribution patterns during decidualization and trophoblast invasion in mouse and human. (2015) Histochem Cell Biol. 144, 571-85

Söhngen L, Schmidt M, Wimberger P, Kimmig R and Grümmer R. Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture. (2014) J Reprod Immunol. 106, 50-7

Dankert D, Demond H, Trapphoff T, Heiligentag M, Rademacher K, Eichenlaub-Ritter U, Horsthemke B and Grümmer R. Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes. (2014) PLoS One. 9, e108907

Demond H, Trapphoff T, Dankert D, Heiligentag M, Grümmer R, Horsthemke B and Eichenlaub-Ritter U. Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. (2016) PLoS One. 11, e0162722

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Ruth Grümmer

References