Room

6. OG R 40

Contact Information

Call: +49 201 723 4290

Email: ruth.gruemmer@uk-essen.de

Ruth Gr├╝mmer

Prof. Dr. rer. nat.

Die Forschungsprojekte von Ruth Gr├╝mmer fokussieren sich auf die┬ámolekularen Mechanismen der weiblichen Reproduktion und ihrer St├Ârungen. Diese umfassen:

 

  • Analyse der zellul├Ąren und molekularen Mechanismen der Pathogenese und Entwicklung neuer Therapieans├Ątze f├╝r die Behandlung der Endometriose
  • Regulation der feto-maternalen Interaktion bei der Embryoimplantation┬á
  • Signalwege und Epithel-Stroma-Interaktion bei der Induktion und Regulation der Dezidualisierung
  • Rolle von Zellkontaktproteinen f├╝r die Dezidualisierung, Implantation und Plazentation
  • Endometriale 2D- und 3D-Zellkultursysteme / Mausmodelle

 

  • The projects of Ruth Gr├╝mmer focus┬áon the molecular mechanisms in female reproduction and their dysfunction. These include:
  • cellular and molecular mechanisms of the pathogenesis and development of novel therapeutical approaches for the treatment of┬áendometriosis
  • regulation of the feto-maternal interaction during embryo implantation
  • signalling and epithel-stromal interaction in the induction and regulation of decidualization
  • role of cell contact proteins for decidualization, implantation and placental development
  • 2D and 3D endometrial cell culture systems / mouse models

References

Grund SC, Wu XX, M├╝ller D, Wennemuth G and Gr├╝mmer R. Impact of endometrial claudin-3 deletion on murine implantation, decidualization and embryo development. (2022) Biol Reprod.
Petri T, Dankert D, Demond H, Wennemuth G, Horsthemke B and Gr├╝mmer R. In vitro postovulatory oocyte aging affects H3K9 trimethylation in two-cell embryos after IVF. (2020) Ann Anat. 227, 151424
Koch Y, Wimberger P and Gr├╝mmer R. Human chorionic gonadotropin induces decidualization of ectopic human endometrium more effectively than forskolin in an in-vivo endometriosis model. (2018) Exp Biol Med (Maywood). 243, 953-962
Grund S and Gr├╝mmer R. Direct CellÔü╗Cell Interactions in the Endometrium and in Endometrial Pathophysiology. (2018) Int J Mol Sci. 19,
Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Fr├Âhlich T, Arnold GJ, Gr├╝mmer R, Horsthemke B and Eichenlaub-Ritter U. Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. (2016) Hum Reprod. 31, 133-49
Schumann S, Buck VU, Classen-Linke I, Wennemuth G and Gr├╝mmer R. Claudin-3, claudin-7, and claudin-10 show different distribution patterns during decidualization and trophoblast invasion in mouse and human. (2015) Histochem Cell Biol. 144, 571-85
S├Âhngen L, Schmidt M, Wimberger P, Kimmig R and Gr├╝mmer R. Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture. (2014) J Reprod Immunol. 106, 50-7
Zahedi Y, Zaun G, Maderwald S, Orzada S, P├╝tter C, Scherag A, Winterhager E, Ladd ME and Gr├╝mmer R. Impact of repetitive exposure to strong static magnetic fields on pregnancy and embryonic development of mice. (2014) J Magn Reson Imaging. 39, 691-9
Dankert D, Demond H, Trapphoff T, Heiligentag M, Rademacher K, Eichenlaub-Ritter U, Horsthemke B and Gr├╝mmer R. Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes. (2014) PLoS One. 9, e108907
Demond H, Trapphoff T, Dankert D, Heiligentag M, Gr├╝mmer R, Horsthemke B and Eichenlaub-Ritter U. Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. (2016) PLoS One. 11, e0162722