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Gunther Wennemuth

Our lab has a broad spectrum in questions concerning reproductive biology and immunology. We investigate Ion- and proton channels as crucial molecules enabling sperm to regulate all of their key functions like motility, hyperactivation or sperm-egg communication.

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Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.


This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

Wiesehöfer, C, Wiesehöfer, M, Dankert, JT, Chung, JJ, von Ostau, NE, Singer, BB, Wennemuth, G (2022). CatSper and its CaM-like Ca2+ sensor EFCAB9 are necessary for the path chirality of sperm. FASEB J36,e22288.

Walwyn-Brown, K, Pugh, J, Cocker, ATH, Beyzaie, N, Singer, BB, Olive, D, Guethlein, LA, Parham, P, Djaoud, Z (2022). Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer-Cell Responses to Missing-Self. Cancer Immunol Res10,558-570.

Klaile, E, Prada Salcedo, JP, Klassert, TE, Besemer, M, Bothe, AK, Durotin, A, Müller, MM, Schmitt, V, Luther, CH, Dittrich, M et al. (2022). Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans. Cell Immunol371,104459.

Taxauer, K, Hamway, Y, Ralser, A, Dietl, A, Mink, K, Vieth, M, Singer, BB, Gerhard, M, Mejías-Luque, R (2021). Engagement of CEACAM1 by Helicobacterpylori HopQ Is Important for the Activation of Non-Canonical NF-κB in Gastric Epithelial Cells. Microorganisms9,.

Galaski, J, Shhadeh, A, Umaña, A, Yoo, CC, Arpinati, L, Isaacson, B, Berhani, O, Singer, BB, Slade, DJ, Bachrach, G et al. (2021). Fusobacterium nucleatum CbpF Mediates Inhibition of T Cell Function Through CEACAM1 Activation. Front Cell Infect Microbiol11,692544.

Turner, MA, Amirfakhri, S, Nishino, H, Lwin, TM, Savides, TJ, Reid, TR, Singer, BB, Hoffman, RM, Bouvet, M . A Patient-Derived Orthotopic Xenograft Model of Gastroesophageal-Junction Adenocarcinoma Translated to the Clinic by Tumor-Targeting Fluorescent Antibodies to Carcinoembryonic-Antigen-Related Cell-Adhesion Molecules. In Vivo35,1959-1963.

Kube, I, Jastrow, H, Führer, D, Zwanziger, D (2021). Thyroid Hormone Deficiency Modifies Hepatic Lipid Droplet Morphology and Molecular Properties in Lithogenic-Diet Supplemented Mice. Exp Clin Endocrinol Diabetes129,926-930.

Busch, M, Miroschnikov, N, Dankert, JT, Wiesehöfer, M, Metz, K, Stephan, H, Dünker, N (2021). Impact of RARα and miR-138 on retinoblastoma etoposide resistance. Tumour Biol43,11-26.

Nishino, H, Hollandsworth, HM, Amirfakhri, S, Tashiro, Y, Yamamoto, J, Turner, MA, Lwin, TM, Singer, BB, Hoffman, RM, Bouvet, M et al. (2021). A Novel Color-Coded Liver Metastasis Mouse Model to Distinguish Tumor and Adjacent Liver Segment. J Surg Res264,327-333.

Wiesehöfer, M, Czyrnik, ED, Spahn, M, Ting, S, Reis, H, Dankert, JT, Wennemuth, G (2021). Increased Expression of AKT3 in Neuroendocrine Differentiated Prostate Cancer Cells Alters the Response Towards Anti-Androgen Treatment. Cancers (Basel)13,.

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Seminar und Veranstaltungen

Ende der Vorlesungszeit

Datum: 4 Februar 2022
Uhrzeit: 12:00 am - 12:00 am

Reproduktions-immunologisches Seminar

Datum: 6 April 2022
Uhrzeit: 12:00 am - 12:00 am

Elena Czyrnik – “Analysis of stroma-epithelial interactions via soluble factors in prostatic cell cultures”

Reproduktions-immunologisches Seminar

Datum: 13 April 2022
Uhrzeit: 12:00 am - 12:00 am

Nell Kniffka – “Characterization of miR-660, mir-378a and CREB5 in prostate carcinoma cells”

Reproduktions-immunologisches Seminar

Datum: 27 April 2022
Uhrzeit: 12:00 am

Lara Suetin – Project progress

Marc Wiesehöfer – “Regulation of epiregulin biosynthesis in prostate carcinoma cells”

Journal Club

Datum: 25 Mai 2022
Uhrzeit: 12:00 pm

Irina Kube-Golovin – Journal Club

Martine Wypich – “Impact of intracellular cAMP on the 4D swimming motion of murine spermatozoa“

Research members
> 4 mill. €
grants received
> 100

Our Team

Bernhard B. Singer

Call: +49 201 723 4389

Caroline Wiesehöfer

Call: +49 201 723 4295

Holger Jastrow

Call: +49 201 723 85746

Irina Kube-Golovin

Call: +49 201 723 4275

Jaroslaw Dankert

Call: +49 201 723 4291

Kirstin Obst-Pernberg

Call: +49 201 723 4391

Marc Wiesehöfer

Call: +49 201 723 4295

Ruth Grümmer

Call: +49 201 723 4290