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Our Team

Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.

CEACAMs:

This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

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Schumann, S, Grund, SC, Dankert, JT, Grümmer, R, Wennemuth, G (2025). Carbonic anhydrase IV deficiency causes intrauterine embryonic loss in mice. Cells Tissues Organs,1-18.

Wilhelm, ED, Dankert, JT, Wiesehöfer, M, Wach, S, Wagner, M, Spahn, M, Kruithof-de Julio, M, Wennemuth, G (2025). xCT as a potential marker for neuroendocrine cells in high-risk prostate cancer and the relation to AL122023.1-miR-26a/30d/30e axis. PLoS One20,e0318213.

Patarrão, RS, Meneses, MJ, Ghadieh, HE, Herrera, L, Duarte, S, Ribeiro, RT, Raposo, JF, Schmitt, V, Singer, BB, Gastaldelli, A et al. (2024). Insights into circulating CEACAM1 in insulin clearance and disease progression: Evidence from the Portuguese PREVADIAB2 study. Eur J Clin Invest54 Suppl 2,e14344.

Fleckenstein, JM, Najjar, SM, Zimmermann, W, Hauck, CR, Nguyen, Q, Mejias-Luque, R, Bhattacharyya, A, McCarthy, AJ, Sarkar, A, Kujawski, M et al. (2024). Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany. Eur J Clin Invest54 Suppl 2,e14355.

Kyrylenko, S, Chorna, I, Klishchova, Z, Yanko, I, Roshchupkin, A, Deineka, V, Diedkova, K, Konieva, A, Petrichenko, O, Kube-Golovin, I et al. (2024). Elucidation of Potential Genotoxicity of MXenes Using a DNA Comet Assay. ACS Appl Bio Mater7,8351-8366.

Sheikh, A, Ganguli, D, Vickers, TJ, Singer, BB, Foulke-Abel, J, Akhtar, M, Khatoon, N, Setu, B, Basu, S, Harro, C et al. (2024). Host-derived CEACAM-laden vesicles engage enterotoxigenic Escherichia coli for elimination and toxin neutralization. Proc Natl Acad Sci U S A121,e2410679121.

Konieva, A, Deineka, V, Diedkova, K, Aguilar-Ferrer, D, Lyndin, M, Wennemuth, G, Korniienko, V, Kyrylenko, S, Lihachev, A, Zahorodna, V et al. (2024). MXene-Polydopamine-antiCEACAM1 Antibody Complex as a Strategy for Targeted Ablation of Melanoma. ACS Appl Mater Interfaces16,43302-43316.

Chen, J, Lin, X, Bhattacharya, S, Wiesehöfer, C, Wennemuth, G, Müller, K, Montag, D (2023). Neuroplastin Expression in Male Mice Is Essential for Fertility, Mating, and Adult Testosterone Levels. Int J Mol Sci25,.

Kube-Golovin, I, Lyndin, M, Wiesehöfer, M, Wennemuth, G (2023). CEACAM expression in an in-vitro prostatitis model. Front Immunol14,1236343.

Czyrnik, ED, Wiesehöfer, M, Dankert, JT, Wach, S, Wagner, M, Spahn, M, Kruithof de Julio, M, Wennemuth, G (2023). Stromal-epithelial interaction induces GALNT14 in prostate carcinoma cells. Front Oncol13,1212585.

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