Gunther Wennemuth

Our lab has a broad spectrum in questions concerning reproductive biology and immunology. We investigate Ion- and proton channels as crucial molecules enabling sperm to regulate all of their key functions like motility, hyperactivation or sperm-egg communication.

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Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.

CEACAMs:

This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

Galaski, J, Shhadeh, A, Umaña, A, Yoo, CC, Arpinati, L, Isaacson, B, Berhani, O, Singer, BB, Slade, DJ, Bachrach, G et al. (2021). Fusobacterium nucleatum CbpF Mediates Inhibition of T Cell Function Through CEACAM1 Activation. Front Cell Infect Microbiol11,692544.

Turner, MA, Amirfakhri, S, Nishino, H, Lwin, TM, Savides, TJ, Reid, TR, Singer, BB, Hoffman, RM, Bouvet, M . A Patient-Derived Orthotopic Xenograft Model of Gastroesophageal-Junction Adenocarcinoma Translated to the Clinic by Tumor-Targeting Fluorescent Antibodies to Carcinoembryonic-Antigen-Related Cell-Adhesion Molecules. In Vivo35,1959-1963.

Kube, I, Jastrow, H, Führer, D, Zwanziger, D (2021). Thyroid Hormone Deficiency Modifies Hepatic Lipid Droplet Morphology and Molecular Properties in Lithogenic-Diet Supplemented Mice. Exp Clin Endocrinol Diabetes,.

Busch, M, Miroschnikov, N, Dankert, JT, Wiesehöfer, M, Metz, K, Stephan, H, Dünker, N (2021). Impact of RARα and miR-138 on retinoblastoma etoposide resistance. Tumour Biol43,11-26.

Nishino, H, Hollandsworth, HM, Amirfakhri, S, Tashiro, Y, Yamamoto, J, Turner, MA, Lwin, TM, Singer, BB, Hoffman, RM, Bouvet, M et al. (2021). A Novel Color-Coded Liver Metastasis Mouse Model to Distinguish Tumor and Adjacent Liver Segment. J Surg Res264,327-333.

Wiesehöfer, M, Czyrnik, ED, Spahn, M, Ting, S, Reis, H, Dankert, JT, Wennemuth, G (2021). Increased Expression of AKT3 in Neuroendocrine Differentiated Prostate Cancer Cells Alters the Response Towards Anti-Androgen Treatment. Cancers (Basel)13,.

van Sorge, NM, Bonsor, DA, Deng, L, Lindahl, E, Schmitt, V, Lyndin, M, Schmidt, A, Nilsson, OR, Brizuela, J, Boero, E et al. (2021). Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors. EMBO J40,e106103.

Ambrosi, C, Scribano, D, Sarshar, M, Zagaglia, C, Singer, BB, Palamara, AT (2020). Acinetobacter baumannii Targets Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAMs) for Invasion of Pneumocytes. mSystems5,.

Mach, P, Andrikos, D, Schmidt, B, Gellhaus, A, Rusch, P, Birdir, C, Andrikos, A, Schmitt, V, Kimmig, R, Singer, BB et al. (2021). Evaluation of carcinoembryonic antigen-related cell adhesion molecule 1 blood serum levels in women at high risk for preeclampsia. Am J Reprod Immunol85,e13375.

Kleszka, K, Leu, T, Quinting, T, Jastrow, H, Pechlivanis, S, Fandrey, J, Schreiber, T (2020). Hypoxia-inducible factor-2α is crucial for proper brain development. Sci Rep10,19146.

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24
Research members
> 4 mill. €
grants received
> 100
publications

Our Team

Bernhard B. Singer

Call: +49 201 723 4389

Caroline Wiesehöfer

Call: +49 201 723 4295

Holger Jastrow

Call: +49 201 723 85746

Irina Kube-Golovin

Call: +49 201 723 4399

Jaroslaw Dankert

Call: +49 201 723 4291

Kirstin Obst-Pernberg

Call: +49 201 723 4399

Marc Wiesehöfer

Call: +49 201 723 4295

Ruth Grümmer

Call: +49 201 723 4290