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Anbau - IG1

Der neue Anbau für digitale Lehre und Praktika macht schnelle Fortschritte!

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3D Struktur von CatSper identifiziert

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Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.

CEACAMs:

This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

Frintrop, L, Wiesehöfer, C, Stoskus, A, Hilken, G, Dubicanac, M, von Ostau, NE, Rode, S, Elgeti, J, Dankert, JT, Wennemuth, G et al. (2022). cAMP and the Fibrous Sheath Protein CABYR (Ca²⁺-Binding Tyrosine-Phosphorylation-Regulated Protein) Is Required for 4D Sperm Movement. Int J Mol Sci23,.

Nishino, H, Turner, MA, Amirfakhri, S, Lwin, TM, Hosseini, M, Singer, BB, Hoffman, RM, Bouvet, M (2023). Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol30,618-625.

Nishino, H, Turner, MA, Amirfakhri, S, Lwin, TM, Hosseini, M, Singer, BB, Hoffman, RM, Bouvet, M (2023). ASO Visual Abstract: Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol30,626-627.

Jaegers, J, Haferkamp, S, Arnolds, O, Moog, D, Wrobeln, A, Nocke, F, Cantore, M, Pütz, S, Hartwig, A, Franzkoch, R et al. (2022). Deciphering the Emulsification Process to Create an Albumin-Perfluorocarbon-(o/w) Nanoemulsion with High Shelf Life and Bioresistivity. Langmuir38,10351-10361.

Contreras, W, Wiesehöfer, C, Schreier, D, Leinung, N, Peche, P, Wennemuth, G, Gentzel, M, Schröder, B, Mentrup, T (2022). C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly. Sci Adv8,eabo6049.

Grund, SC, Wu, XX, Müller, D, Wennemuth, G, Grümmer, R (2022). Impact of endometrial claudin-3 deletion on murine implantation, decidualization, and embryo development†. Biol Reprod107,984-997.

Zhao, Y, Wang, H, Wiesehoefer, C, Shah, NB, Reetz, E, Hwang, JY, Huang, X, Wang, TE, Lishko, PV, Davies, KM et al. (2022). 3D structure and in situ arrangements of CatSper channel in the sperm flagellum. Nat Commun13,3439.

Kyrylenko, S, Gogotsi, O, Baginskiy, I, Balitskyi, V, Zahorodna, V, Husak, Y, Yanko, I, Pernakov, M, Roshchupkin, A, Lyndin, M et al. (2022). MXene-Assisted Ablation of Cells with a Pulsed Near-Infrared Laser. ACS Appl Mater Interfaces14,28683-28696.

Zaffran, I, Landolina, N, Gaur, P, Rovis, TL, Stipan, J, Mandelboim, O, Singer, BB, Levi-Schaffer, F (2022). Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells. Cancer Gene Ther29,1676-1685.

Wiesehöfer, C, Wiesehöfer, M, Dankert, JT, Chung, JJ, von Ostau, NE, Singer, BB, Wennemuth, G (2022). CatSper and its CaM-like Ca²⁺ sensor EFCAB9 are necessary for the path chirality of sperm. FASEB J36,e22288.

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