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Gunther Wennemuth

Our lab has a broad spectrum in questions concerning reproductive biology and immunology. We investigate Ion- and proton channels as crucial molecules enabling sperm to regulate all of their key functions like motility, hyperactivation or sperm-egg communication.

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Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.

CEACAMs:

This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

Zhou, S, Xie, L, Zhang, X, Yan, M, Zeng, H, Liang, K, Jiang, L, Kong, B (2022). Super-Assembled multi-Level asymmetric mesochannels for coupled accelerated dual-Ion selective transport. Adv Mater,e2208903.

Zhang, Y, Jiang, K, Liu, P, Tang, Y, Li, G, Xiong, A, Yang, L, Wang, Z (2022). Mechanism of triterpenoids from Alismatis Rhizoma against liver fibrosis based on an integrated approach using network pharmacology, molecular docking, and luciferase assay. Nat Prod Res,1-6.

Schuler, BR, Collins, BN, Scheuermann, TS, Baishya, M, Kilby, L, Lepore, SJ (2022). Translating pediatric primary care best practice guidelines for addressing tobacco in the WIC system. Transl Behav Med,.

Xu, H, Xu, S, Li, L, Wu, Y, Mai, S, Xie, Y, Tan, Y, Li, A, Xue, F, He, X et al. (2022). Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury. Chin Med17,131.

Liu, L, Zhang, B, Yang, Y, Qi, L, Wang, S, Meng, L, Ma, W, Huo, Y (2022). Reduced left atrial contractile strain with speckle tracking analysis predicts abnormal plasma NTproBNP in an asymptomatic community population. Cardiovasc Ultrasound20,27.

Levesque, A, Béliveau, J, Ogez, D, Marcil, V, Curnier, D, Laverdière, C, Sinnett, D, Péloquin, K, Sultan, S (2022). Do problem-solving skills help mitigate emotional distress through perceived control and self-efficacy in parents of children with cancer?. Psychooncology,.

Zheng, JX, Lv, S, Tian, LG, Guo, ZY, Zheng, PY, Chen, YL, Guan, SY, Wang, WM, Zhang, SX (2022). The rapid and efficient strategy for SARS-CoV-2 Omicron transmission control: analysis of outbreaks at the city level. Infect Dis Poverty11,114.

Willburger, RE, Oberberg, S (2022). Early and mid-term results with the ATTUNE total knee replacement system compared to PFC Sigma: a prospective comparative study. J Orthop Surg Res17,509.

Federico, G, Cavaliere, C, Reynaud, E, Salvatore, M, Brandimonte, MA, Osiurak, F (2022). The Area Prostriata may play a role in technical reasoning. Behav Brain Funct18,12.

Zhang, Z, Zhang, C, Li, Y, Wang, C, Yu, Q (2022). Lipid and metabolic alteration involvement in physiotherapy for chronic nonspecific low back pain. Lipids Health Dis21,125.

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Seminar und Veranstaltungen

Journal Club

Datum: 7 Dezember 2022
Uhrzeit: 12:00 pm

Ruth Grümmer: „Journal Club“

Journal Club

Datum: 14 Dezember 2022
Uhrzeit: 12:00 pm

Bernhard B. Singer: „Journal Club“

Projekt

Datum: 21 Dezember 2022
Uhrzeit: 12:00 pm

Martine Weyrich: „Projekt“

Projekt

Datum: 11 Januar 2023
Uhrzeit: 12:00 pm

Anastasiia Konieva: „Projekt“

Journal Club

Datum: 18 Januar 2023
Uhrzeit: 12:00 pm

Kirstin Obst-Pernberg: „Journal Club“

24
Research members
> 4 mill. €
grants received
> 100
publications

Our Team

Bernhard B. Singer

Call: +49 201 723 4389

Caroline Wiesehöfer

Call: +49 201 723 4295

Holger Jastrow

Call: +49 201 723 85746

Irina Kube-Golovin

Call: +49 201 723 4275

Jaroslaw Dankert

Call: +49 201 723 4291

Kirstin Obst-Pernberg

Call: +49 201 723 4391

Marc Wiesehöfer

Call: +49 201 723 4295

Ruth GrĂĽmmer

Call: +49 201 723 4290