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Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.

CEACAMs:

This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

Catton, EA, Bonsor, DA, Herrera, C, Stålhammar-Carlemalm, M, Lyndin, M, Turner, CE, Soden, J, van Strijp, JAG, Singer, BB, van Sorge, NM et al. (2023). Author Correction: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis. Nat Commun14,2675.

Muturi, HT, Ghadieh, HE, Abdolahipour, R, Stankus, HL, Belew, GD, Liu, JK, Jahromi, MS, Lee, AD, Singer, BB, Angeli-Pahim, I et al. (2023). Loss of CEACAM1 in endothelial cells causes hepatic fibrosis. Metabolism144,155562.

Catton, EA, Bonsor, DA, Herrera, C, Stålhammar-Carlemalm, M, Lyndin, M, Turner, CE, Soden, J, van Strijp, JAG, Singer, BB, van Sorge, NM et al. (2023). Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis. Nat Commun14,2275.

Platt, F, Moyer, J, Singer, BB, Baston-Büst, D, Wennemuth, G, Bielfeld, AP, Grümmer, R (2023). Forskolin versus cAMP-Induced Decidualization and Survival of Endometrial Stromal Cells of Endometriosis Patients. Reprod Sci,.

Wiesehöfer, M, Raczinski, BBG, Wiesehöfer, C, Dankert, JT, Czyrnik, ED, Spahn, M, Kruithof-de Julio, M, Wennemuth, G (2023). Epiregulin expression and secretion is increased in castration-resistant prostate cancer. Front Oncol13,1107021.

Zaffran, I, Landolina, N, Gaur, P, Rovis, TL, Jonjic, S, Mandelboim, O, Singer, BB, Levi-Schaffer, F (2023). Correction to: Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells. Cancer Gene Ther,.

Frintrop, L, Wiesehöfer, C, Stoskus, A, Hilken, G, Dubicanac, M, von Ostau, NE, Rode, S, Elgeti, J, Dankert, JT, Wennemuth, G et al. (2022). cAMP and the Fibrous Sheath Protein CABYR (Ca²⁺-Binding Tyrosine-Phosphorylation-Regulated Protein) Is Required for 4D Sperm Movement. Int J Mol Sci23,.

Nishino, H, Turner, MA, Amirfakhri, S, Lwin, TM, Hosseini, M, Singer, BB, Hoffman, RM, Bouvet, M (2023). Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol30,618-625.

Nishino, H, Turner, MA, Amirfakhri, S, Lwin, TM, Hosseini, M, Singer, BB, Hoffman, RM, Bouvet, M (2023). ASO Visual Abstract: Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol30,626-627.

Jaegers, J, Haferkamp, S, Arnolds, O, Moog, D, Wrobeln, A, Nocke, F, Cantore, M, Pütz, S, Hartwig, A, Franzkoch, R et al. (2022). Deciphering the Emulsification Process to Create an Albumin-Perfluorocarbon-(o/w) Nanoemulsion with High Shelf Life and Bioresistivity. Langmuir38,10351-10361.

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