Anbau - IG1

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HopQ und CEACAM Bindung können in der Therapie des Kolonkarzinoms hilfreich sein.

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Digitale Histologie

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Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.

CEACAMs:

This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

Hollandsworth, HM, Schmitt, V, Amirfakhri, S, Filemoni, F, Schmidt, A, Landström, M, Lyndin, M, Backert, S, Gerhard, M, Wennemuth, G et al. (2020). Fluorophore-conjugated Helicobacter pylori recombinant membrane protein (HopQ) labels primary colon cancer and metastases in orthotopic mouse models by binding CEA-related cell adhesion molecules. Transl Oncol13,100857.

Arlt, E, Fraticelli, M, Tsvilovskyy, V, Nadolni, W, Breit, A, O'Neill, TJ, Resenberger, S, Wennemuth, G, Wahl-Schott, C, Biel, M et al. (2020). TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity. Proc. Natl. Acad. Sci. U.S.A.117,18068-18078.

Zöller, J, Ebel, JF, Khairnar, V, Schmitt, V, Klopfleisch, R, Meiners, J, Seiffart, V, Hansen, W, Buer, J, Singer, BB et al. (2020). CEACAM1 regulates CD8⁺ T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitis. Gut Microbes11,1790-1805.

Tegtmeyer, N, Ghete, TD, Schmitt, V, Remmerbach, T, Cortes, MCC, Bondoc, EM, Graf, HL, Singer, BB, Hirsch, C, Backert, S et al. (2020). Type IV secretion of Helicobacter pylori CagA into oral epithelial cells is prevented by the absence of CEACAM receptor expression. Gut Pathog12,25.

Hamway, Y, Taxauer, K, Moonens, K, Neumeyer, V, Fischer, W, Schmitt, V, Singer, BB, Remaut, H, Gerhard, M, Mejías-Luque, R et al. (2020). Cysteine Residues in Helicobacter pylori Adhesin HopQ are Required for CEACAM-HopQ Interaction and Subsequent CagA Translocation. Microorganisms8,.

Lang, J, Bohn, P, Bhat, H, Jastrow, H, Walkenfort, B, Cansiz, F, Fink, J, Bauer, M, Olszewski, D, Ramos-Nascimento, A et al. (2020). Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun11,1338.

Hollandsworth, HM, Amirfakhri, S, Filemoni, F, Schmitt, V, Wennemuth, G, Schmidt, A, Hoffman, RM, Singer, BB, Bouvet, M (2020). Anti-carcinoembryonic antigen-related cell adhesion molecule antibody for fluorescence visualization of primary colon cancer and metastases in patient-derived orthotopic xenograft mouse models. Oncotarget11,429-439.

Czyrnik, ED, Wiesehöfer, M, Dankert, JT, Wennemuth, G (2020). The regulation of HAS3 by miR-10b and miR-29a in neuroendocrine transdifferentiated LNCaP prostate cancer cells. Biochem. Biophys. Res. Commun.523,713-718.

Kontopoulou, E, Strachan, S, Reinhardt, K, Kunz, F, Walter, C, Walkenfort, B, Jastrow, H, Hasenberg, M, Giebel, B, von Neuhoff, N et al. (2020). Evaluation of dsDNA from extracellular vesicles (EVs) in pediatric AML diagnostics. Ann. Hematol.99,459-475.

Klaile, E, Müller, MM, Zubiría-Barrera, C, Brehme, S, Klassert, TE, Stock, M, Durotin, A, Nguyen, TD, Feer, S, Singer, BB et al. (2019). Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic Infection. Front Microbiol10,2703.

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