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    3D Struktur von CatSper identifiziert

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Gunther Wennemuth

Our lab has a broad spectrum in questions concerning reproductive biology and immunology. We investigate Ion- and proton channels as crucial molecules enabling sperm to regulate all of their key functions like motility, hyperactivation or sperm-egg communication.

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Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.


This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

Grund, SC, Wu, XX, M├╝ller, D, Wennemuth, G, Gr├╝mmer, R (2022). Impact of endometrial claudin-3 deletion on murine implantation, decidualization and embryo development. Biol Reprod,.

Zhao, Y, Wang, H, Wiesehoefer, C, Shah, NB, Reetz, E, Hwang, JY, Huang, X, Wang, TE, Lishko, PV, Davies, KM et al. (2022). 3D structure and in situ arrangements of CatSper channel in the sperm flagellum. Nat Commun13,3439.

Kyrylenko, S, Gogotsi, O, Baginskiy, I, Balitskyi, V, Zahorodna, V, Husak, Y, Yanko, I, Pernakov, M, Roshchupkin, A, Lyndin, M et al. (2022). MXene-Assisted Ablation of Cells with a Pulsed Near-Infrared Laser. ACS Appl Mater Interfaces14,28683-28696.

Zaffran, I, Landolina, N, Gaur, P, Rovis, TL, Stipan, J, Mandelboim, O, Singer, BB, Levi-Schaffer, F (2022). Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells. Cancer Gene Ther,.

Wieseh├Âfer, C, Wieseh├Âfer, M, Dankert, JT, Chung, JJ, von Ostau, NE, Singer, BB, Wennemuth, G (2022). CatSper and its CaM-like Ca2+ sensor EFCAB9 are necessary for the path chirality of sperm. FASEB J36,e22288.

Walwyn-Brown, K, Pugh, J, Cocker, ATH, Beyzaie, N, Singer, BB, Olive, D, Guethlein, LA, Parham, P, Djaoud, Z (2022). Phosphoantigen-Stimulated ╬│╬┤ T Cells Suppress Natural Killer-Cell Responses to Missing-Self. Cancer Immunol Res10,558-570.

Klaile, E, Prada Salcedo, JP, Klassert, TE, Besemer, M, Bothe, AK, Durotin, A, M├╝ller, MM, Schmitt, V, Luther, CH, Dittrich, M et al. (2022). Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans. Cell Immunol371,104459.

Taxauer, K, Hamway, Y, Ralser, A, Dietl, A, Mink, K, Vieth, M, Singer, BB, Gerhard, M, Mej├şas-Luque, R (2021). Engagement of CEACAM1 by Helicobacterpylori HopQ Is Important for the Activation of Non-Canonical NF-╬║B in Gastric Epithelial Cells. Microorganisms9,.

Galaski, J, Shhadeh, A, Uma├▒a, A, Yoo, CC, Arpinati, L, Isaacson, B, Berhani, O, Singer, BB, Slade, DJ, Bachrach, G et al. (2021). Fusobacterium nucleatum CbpF Mediates Inhibition of T Cell Function Through CEACAM1 Activation. Front Cell Infect Microbiol11,692544.

Turner, MA, Amirfakhri, S, Nishino, H, Lwin, TM, Savides, TJ, Reid, TR, Singer, BB, Hoffman, RM, Bouvet, M . A Patient-Derived Orthotopic Xenograft Model of Gastroesophageal-Junction Adenocarcinoma Translated to the Clinic by Tumor-Targeting Fluorescent Antibodies to Carcinoembryonic-Antigen-Related Cell-Adhesion Molecules. In Vivo35,1959-1963.

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Seminar und Veranstaltungen

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Research members
> 4 mill. ÔéČ
grants received
> 100

Our Team

Bernhard B. Singer

Call: +49 201 723 4389

Caroline Wieseh├Âfer

Call: +49 201 723 4295

Holger Jastrow

Call: +49 201 723 85746

Irina Kube-Golovin

Call: +49 201 723 4275

Jaroslaw Dankert

Call: +49 201 723 4291

Kirstin Obst-Pernberg

Call: +49 201 723 4391

Marc Wieseh├Âfer

Call: +49 201 723 4295

Ruth Gr├╝mmer

Call: +49 201 723 4290