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Gunther Wennemuth

Our lab has a broad spectrum in questions concerning reproductive biology and immunology. We investigate Ion- and proton channels as crucial molecules enabling sperm to regulate all of their key functions like motility, hyperactivation or sperm-egg communication.

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Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.

CEACAMs:

This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

Kube-Golovin, I, Lyndin, M, Wieseh├Âfer, M, Wennemuth, G (2023). CEACAM expression in an in-vitro prostatitis model. Front Immunol14,1236343.

Czyrnik, ED, Wieseh├Âfer, M, Dankert, JT, Wach, S, Wagner, M, Spahn, M, Kruithof de Julio, M, Wennemuth, G (2023). Stromal-epithelial interaction induces GALNT14 in prostate carcinoma cells. Front Oncol13,1212585.

Corsaro, D, M├╝ller, KD, Mosel, F, Jastrow, H, Walochnik, J, Michel, R (2023). On predatory fungi feeding on free-living amoebae harbouring yeast-like endoparasites. Parasitol Res122,2385-2392.

Catton, EA, Bonsor, DA, Herrera, C, St├ąlhammar-Carlemalm, M, Lyndin, M, Turner, CE, Soden, J, van Strijp, JAG, Singer, BB, van Sorge, NM et al. (2023). Author Correction: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis. Nat Commun14,2675.

Muturi, HT, Ghadieh, HE, Abdolahipour, R, Stankus, HL, Belew, GD, Liu, JK, Jahromi, MS, Lee, AD, Singer, BB, Angeli-Pahim, I et al. (2023). Loss of CEACAM1 in endothelial cells causes hepatic fibrosis. Metabolism144,155562.

Catton, EA, Bonsor, DA, Herrera, C, St├ąlhammar-Carlemalm, M, Lyndin, M, Turner, CE, Soden, J, van Strijp, JAG, Singer, BB, van Sorge, NM et al. (2023). Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis. Nat Commun14,2275.

Platt, F, Moyer, J, Singer, BB, Baston-B├╝st, D, Wennemuth, G, Bielfeld, AP, Gr├╝mmer, R (2023). Forskolin versus cAMP-Induced Decidualization and Survival of Endometrial Stromal Cells of Endometriosis Patients. Reprod Sci30,2680-2691.

Wieseh├Âfer, M, Raczinski, BBG, Wieseh├Âfer, C, Dankert, JT, Czyrnik, ED, Spahn, M, Kruithof-de Julio, M, Wennemuth, G (2023). Epiregulin expression and secretion is increased in castration-resistant prostate cancer. Front Oncol13,1107021.

Zaffran, I, Landolina, N, Gaur, P, Rovis, TL, Jonjic, S, Mandelboim, O, Singer, BB, Levi-Schaffer, F (2023). Correction to: Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells. Cancer Gene Ther30,926.

Frintrop, L, Wieseh├Âfer, C, Stoskus, A, Hilken, G, Dubicanac, M, von Ostau, NE, Rode, S, Elgeti, J, Dankert, JT, Wennemuth, G et al. (2022). cAMP and the Fibrous Sheath Protein CABYR (Ca2+-Binding Tyrosine-Phosphorylation-Regulated Protein) Is Required for 4D Sperm Movement. Int J Mol Sci23,.

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Seminar und Veranstaltungen

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26
Research members
> 4 mill. ÔéČ
grants received
> 100
publications

Our Team

Anastasiia Konieva

Call: +49 201 723 4399

Caroline Wieseh├Âfer

Call: +49 201 723 4295

Holger Jastrow

Call: +49 201 723 85746

Irina Kube-Golovin

Call: +49 201 723 4376

Janine Moyer

Call: +49 201 723 4376

Jaroslaw Dankert

Call: +49 201 723 4291

Kirstin Obst-Pernberg

Call: +49 201 723 4391

Marc Wieseh├Âfer

Call: +49 201 723 4295

Mykola Lyndin

Call: +49 201 723 4399

Ruth Gr├╝mmer

Call: +49 201 723 4290