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    3D Struktur von CatSper identifiziert

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Gunther Wennemuth

Our lab has a broad spectrum in questions concerning reproductive biology and immunology. We investigate Ion- and proton channels as crucial molecules enabling sperm to regulate all of their key functions like motility, hyperactivation or sperm-egg communication.

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Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.

CEACAMs:

This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Latest publications

Frintrop, L, Wiesehöfer, C, Stoskus, A, Hilken, G, Dubicanac, M, von Ostau, NE, Rode, S, Elgeti, J, Dankert, JT, Wennemuth, G et al. (2022). cAMP and the Fibrous Sheath Protein CABYR (Ca2+-Binding Tyrosine-Phosphorylation-Regulated Protein) Is Required for 4D Sperm Movement. Int J Mol Sci23,.

Nishino, H, Turner, MA, Amirfakhri, S, Lwin, TM, Hosseini, M, Singer, BB, Hoffman, RM, Bouvet, M (2023). Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol30,618-625.

Nishino, H, Turner, MA, Amirfakhri, S, Lwin, TM, Hosseini, M, Singer, BB, Hoffman, RM, Bouvet, M (2023). ASO Visual Abstract: Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model. Ann Surg Oncol30,626-627.

Jaegers, J, Haferkamp, S, Arnolds, O, Moog, D, Wrobeln, A, Nocke, F, Cantore, M, PĂĽtz, S, Hartwig, A, Franzkoch, R et al. (2022). Deciphering the Emulsification Process to Create an Albumin-Perfluorocarbon-(o/w) Nanoemulsion with High Shelf Life and Bioresistivity. Langmuir38,10351-10361.

Contreras, W, Wiesehöfer, C, Schreier, D, Leinung, N, Peche, P, Wennemuth, G, Gentzel, M, Schröder, B, Mentrup, T (2022). C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly. Sci Adv8,eabo6049.

Grund, SC, Wu, XX, MĂĽller, D, Wennemuth, G, GrĂĽmmer, R (2022). Impact of endometrial claudin-3 deletion on murine implantation, decidualization, and embryo development†. Biol Reprod107,984-997.

Zhao, Y, Wang, H, Wiesehoefer, C, Shah, NB, Reetz, E, Hwang, JY, Huang, X, Wang, TE, Lishko, PV, Davies, KM et al. (2022). 3D structure and in situ arrangements of CatSper channel in the sperm flagellum. Nat Commun13,3439.

Kyrylenko, S, Gogotsi, O, Baginskiy, I, Balitskyi, V, Zahorodna, V, Husak, Y, Yanko, I, Pernakov, M, Roshchupkin, A, Lyndin, M et al. (2022). MXene-Assisted Ablation of Cells with a Pulsed Near-Infrared Laser. ACS Appl Mater Interfaces14,28683-28696.

Zaffran, I, Landolina, N, Gaur, P, Rovis, TL, Stipan, J, Mandelboim, O, Singer, BB, Levi-Schaffer, F (2022). Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells. Cancer Gene Ther29,1676-1685.

Wiesehöfer, C, Wiesehöfer, M, Dankert, JT, Chung, JJ, von Ostau, NE, Singer, BB, Wennemuth, G (2022). CatSper and its CaM-like Ca2+ sensor EFCAB9 are necessary for the path chirality of sperm. FASEB J36,e22288.

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Seminar und Veranstaltungen

Projekt

Datum: 1 Februar 2023
Uhrzeit: 12:00 pm

Lara Suetin: „Projekt“

Projekt

Datum: 5 April 2023
Uhrzeit: 12:00 pm

Irina Kube: „Projekt“

Projekt

Datum: 12 April 2023
Uhrzeit: 12:00 pm

Aura Stoskus: „Projekt“

Projekt

Datum: 19 April 2023
Uhrzeit: 12:00 pm

Caroline Wiesehöfer: „Projekt“

Projekt

Datum: 26 April 2023
Uhrzeit: 12:00 pm

Nell Kniffka: „Projekt“

24
Research members
> 4 mill. €
grants received
> 100
publications

Our Team

Bernhard B. Singer

Call: +49 201 723 4389

Caroline Wiesehöfer

Call: +49 201 723 4295

Holger Jastrow

Call: +49 201 723 85746

Irina Kube-Golovin

Call: +49 201 723 4275

Jaroslaw Dankert

Call: +49 201 723 4291

Kirstin Obst-Pernberg

Call: +49 201 723 4391

Marc Wiesehöfer

Call: +49 201 723 4295

Ruth GrĂĽmmer

Call: +49 201 723 4290