Deprecated: Optional parameter $atts declared before required parameter $content is implicitly treated as a required parameter in /mnt/web523/b3/22/54057122/htdocs/WordPress_04_Anatomie_Homepage/wp-content/uploads/kc_extensions/icon-hover-effects/index.php on line 138 Deprecated: Optional parameter $atts declared before required parameter $content is implicitly treated as a required parameter in /mnt/web523/b3/22/54057122/htdocs/WordPress_04_Anatomie_Homepage/wp-content/uploads/kc_extensions/cube-box/index.php on line 233 Deprecated: Optional parameter $atts declared before required parameter $content is implicitly treated as a required parameter in /mnt/web523/b3/22/54057122/htdocs/WordPress_04_Anatomie_Homepage/wp-content/uploads/kc_extensions/highlight-box/index.php on line 175 Deprecated: Optional parameter $atts declared before required parameter $content is implicitly treated as a required parameter in /mnt/web523/b3/22/54057122/htdocs/WordPress_04_Anatomie_Homepage/wp-content/uploads/kc_extensions/dual-text/index.php on line 131 Deprecated: Optional parameter $atts declared before required parameter $content is implicitly treated as a required parameter in /mnt/web523/b3/22/54057122/htdocs/WordPress_04_Anatomie_Homepage/wp-content/uploads/kc_extensions/fancy-text/index.php on line 223 Deprecated: Optional parameter $atts declared before required parameter $content is implicitly treated as a required parameter in /mnt/web523/b3/22/54057122/htdocs/WordPress_04_Anatomie_Homepage/wp-content/uploads/kc_extensions/text-animations/index.php on line 245 Anatomie-Essen Deprecated: uksort(): Returning bool from comparison function is deprecated, return an integer less than, equal to, or greater than zero in /mnt/web523/b3/22/54057122/htdocs/WordPress_04_Anatomie_Homepage/wp-content/plugins/kingcomposer/includes/kc.functions.php on line 860

Gunther Wennemuth

Our lab has a broad spectrum in questions concerning reproductive biology and immunology. We investigate Ion- and proton channels as crucial molecules enabling sperm to regulate all of their key functions like motility, hyperactivation or sperm-egg communication.

Welcome to our website!

We have put together a lot of helpful information for you.


You can find out more about our research and teaching as well as our team members.


You will also find important links to job advertisements, doctoral matters and much more.

Herzlich willkommen auf unserer Webseite!


Wir haben für Sie eine Menge hilfreicher Informationen zusammengestellt.


Sie können sich über unsere Forschung und Lehre sowie unsere Teammitglieder informieren.


Zudem finden Sie wichtige Links zu Stellenausschreibungen, Promotionsangelegenheiten und vieles mehr.

Our Research / Unsere Forschung

Male reproduction:

All areas of signaling in reproduction are of interest to our group.
We identify and characterize molecules important for spermatogenesis, early and late activation of spermatozoa and cell-egg interaction. We also focus on cell-cell interaction in testis and prostate cells.

Female reproduction:

This project focuses on the detailed cellular mechanisms in female reproduction and their function and dysfunction in mouse and human. This includes therapeutical approaches to endometriosis, gene regulation of feto-maternal interaction and oocyte development and oocyte aging.

Prostate cancer:

microRNAs play an important role in post transcriptional regulation of the gene regulatory pathways of most cells. This project focuses on the importance of microRNAs for prostate cancer development and progression in animal models as well as in in-vitro experiments.

CEACAMs:

This work deals with the role of CEACAMs in infection, inflammation and wound healing. We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, glycoproteins, celllines and mouse are generated as tools.

Our Team

Anastasiia Konieva

Call: +49 201 723 4399

Caroline Wiesehöfer

Call: +49 201 723 4295

Holger Jastrow

Call: +49 201 723 85746

Irina Kube-Golovin

Call: +49 201 723 4389

Jaroslaw Dankert

Call: +49 201 723 4291

Kirstin Obst-Pernberg

Call: +49 201 723 4391

Marc Wiesehöfer

Call: +49 201 723 4295

Mykola Lyndin

Call: +49 201 723 4399

Ruth Grümmer

Call: +49 201 723 4290

Latest publications

Deprecated: Creation of dynamic property wpPubMedRefList::$query is deprecated in /mnt/web523/b3/22/54057122/htdocs/WordPress_04_Anatomie_Homepage/wp-content/plugins/wp-pubmed-reflist/class.wpPubMedRefList.php on line 32

Schiemann, P, Janicot, M, Wennemuth, G, Lyndin, M, Moyer, J (2025). PCO25-210: Design of Novel Antibody Drug Conjugates Using a Fully Humanized Monoclonal Antibody Targeting the Human Neuronal Pentraxin Receptor (YB800-ADCs) for Therapeutic Intervention in Oncology. J Natl Compr Canc Netw23,.

Schumann, S, Grund, SC, Dankert, JT, Grümmer, R, Wennemuth, G (2025). Carbonic Anhydrase IV Deficiency Causes Intrauterine Embryonic Loss in Mice. Cells Tissues Organs,1-11.

Wilhelm, ED, Dankert, JT, Wiesehöfer, M, Wach, S, Wagner, M, Spahn, M, Kruithof-de Julio, M, Wennemuth, G (2025). xCT as a potential marker for neuroendocrine cells in high-risk prostate cancer and the relation to AL122023.1-miR-26a/30d/30e axis. PLoS One20,e0318213.

Patarrão, RS, Meneses, MJ, Ghadieh, HE, Herrera, L, Duarte, S, Ribeiro, RT, Raposo, JF, Schmitt, V, Singer, BB, Gastaldelli, A et al. (2024). Insights into circulating CEACAM1 in insulin clearance and disease progression: Evidence from the Portuguese PREVADIAB2 study. Eur J Clin Invest54 Suppl 2,e14344.

Fleckenstein, JM, Najjar, SM, Zimmermann, W, Hauck, CR, Nguyen, Q, Mejias-Luque, R, Bhattacharyya, A, McCarthy, AJ, Sarkar, A, Kujawski, M et al. (2024). Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany. Eur J Clin Invest54 Suppl 2,e14355.

Kyrylenko, S, Chorna, I, Klishchova, Z, Yanko, I, Roshchupkin, A, Deineka, V, Diedkova, K, Konieva, A, Petrichenko, O, Kube-Golovin, I et al. (2024). Elucidation of Potential Genotoxicity of MXenes Using a DNA Comet Assay. ACS Appl Bio Mater7,8351-8366.

Sheikh, A, Ganguli, D, Vickers, TJ, Singer, BB, Foulke-Abel, J, Akhtar, M, Khatoon, N, Setu, B, Basu, S, Harro, C et al. (2024). Host-derived CEACAM-laden vesicles engage enterotoxigenic Escherichia coli for elimination and toxin neutralization. Proc Natl Acad Sci U S A121,e2410679121.

Konieva, A, Deineka, V, Diedkova, K, Aguilar-Ferrer, D, Lyndin, M, Wennemuth, G, Korniienko, V, Kyrylenko, S, Lihachev, A, Zahorodna, V et al. (2024). MXene-Polydopamine-antiCEACAM1 Antibody Complex as a Strategy for Targeted Ablation of Melanoma. ACS Appl Mater Interfaces16,43302-43316.

Chen, J, Lin, X, Bhattacharya, S, Wiesehöfer, C, Wennemuth, G, Müller, K, Montag, D (2023). Neuroplastin Expression in Male Mice Is Essential for Fertility, Mating, and Adult Testosterone Levels. Int J Mol Sci25,.

Kube-Golovin, I, Lyndin, M, Wiesehöfer, M, Wennemuth, G (2023). CEACAM expression in an in-vitro prostatitis model. Front Immunol14,1236343.

Search PubMed

Seminar und Veranstaltungen

Manuel Becht

Datum: 18 Juni 2025
Uhrzeit: 12:00 pm - 1:00 pm
Ort: Universitätsklinikum Essen - IG1 5.OG - R8 Bibliothek

Progress Report

Dr. Irina Kube-Golovin

Datum: 25 Juni 2025
Uhrzeit: 12:00 pm - 1:00 pm
Ort: Universitätsklinikum Essen - IG1 5.OG - R8 Bibliothek

Journal Club

Anastasiia Konieva

Datum: 2 Juli 2025
Uhrzeit: 12:00 pm - 1:00 pm

Progress Report

PD Dr. Jaroslaw Dankert

Datum: 16 Juli 2025
Uhrzeit: 12:00 pm - 1:00 pm
Ort: Universitätsklinikum Essen - IG1 5.OG - R8 Bibliothek

Progress Report

Ende der Vorlesungszeit

Datum: 18 Juli 2025
Uhrzeit: 12:00 am - 12:00 am
26
Research members
> 4 mill. €
grants received
> 100
publications